Comment · Mon, June 17, 2019 · Natrium Health & Nootropics Depot
Pomegranate compound with anti-aging effects passes human trial
What they were answering
JetSetKyle · 39 points
Urolithin A looks very promising as a general anti-aging compound.
The paper, published today, also confirms that the compound is safe to eat. Amazentis, based at EPFL's Innovation Park, hopes to harness the promising results to quickly bring the product to market. "These latest findings, which build on previous preclinical trials, really crystallize how UA could be a game-changer for human health," says Johan Auwerx, a professor at LISP, the EPFL lab involved in the trial. An article published in 2016 showed that the lifespan of nematode worms exposed to UA increased by 45 percent—from around 20 to 30 days—when compared with the control group. Likewise, older mice showed 40 percent better endurance while running after two weeks of treatment. The compound may thus have even more secrets to reveal about its benefits for human health.
There doesn't seem to be any Urolithin A specific supplements on the market today, however Nootropics Depot's Pomella product is probably the closest we can get. It is hard to say how much Urolithin A is in Pomella - looks like you may need to take 2-3 pills to get the full dose.
Also does anyone know or can speculate on the optimal age to start anti-aging routines?
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Urolithin A is a metabolite of the punicalagins in Pomella. There are even studies on Pomella and this compound. We mention Urolithin A on our product page as well.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359844/
Of the polyphenols, the chemopreventive pomegranate ellagitannins (e.g., punicalagin and punicalin) are metabolized during absorption. One of the metabolites, ellagic acid, is further metabolized by the colonic microflora to urolithin A. Both ellagic acid and urolithin A contribute to the mechanism of anticancer action, but urolithin was less effective in inhibiting cancer cell proliferation [20–22]. There was no difference in metabolite production between pomegranate juice and extracts thereof [23], though inactive ellagitannin-derived metabolites are also produced by the colonic microflora [24]. This may account for individual differences in the response to pomegranate consumption.