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Comment · Tue, September 18, 2018 · Natrium Health & Nootropics Depot

Studies show that Amphetamine sensitization occurs in Healthy Individuals after just 3 intermittent dosing with 20mg d-amphetamine. Is it dangerous?

Original post in this thread

tronatula · 101 points

[[full text] The amphetamine-induced sensitized state as a model of schizophrenia](https://drive.google.com/open?id=1BM1QZHpVcwzG9bEtRLWli5vn5KU0_qTz)

[[full text] Modeling Sensitization to Stimulants in Humans](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/209916)

[[full text] Enhanced behavioral response to repeated d-amphetamine and personality traits in humans](https://drive.google.com/file/d/1J1r2AUg4b3ZraHDsx3wyS6PyTWcfBIfS/view?usp=sharing)

Dosages in 3 studies above are ~20mg d-amphetamine (Dexerine) on day 1,3 and 5. No need for microdosing and the phenomenon persists for at least 1 year. The question is:

If Amphetamine sensitization is indeed dangerous, why is it rarely mentioned in studies about Prescription Stimulant Medication Misuse? Why they keep recruit healthy individuals to make them sensitized? Why is amphetamine approved for ADHD? Isn't it too easy to get amphetamine sensitization?

What they were answering

bitieubom · 6 points

Pinging /u/MisterYouAreSoDumb , so is it ok to take Adderall for studying?

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

When properly prescribed by a doctor, and taken in the appropriate amounts, amphetamine is relatively safe. However, it does lead to long-lasting changes in the brain. Those changes are likely not something to worry about if you are not abusing it.

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