The neurotoxic mechanisms of amphetamine: Step by step for striatal dopamine depletion -

Comment · Fri, November 24, 2017 · 19 pts

Absolutely. Amphetamine can be neurotoxic in certain instances. That's usually dosage-dependent, but even long-term use of lower doses can lead to neurodegeneration. This seems to be especially true in younger people. [

Comment · Mon, November 27, 2017 · 6 pts

Well there seems to be a line that needs to be crossed in the amount of dopamine released that causes the issue. This is why most of the damage seen is dose-dependent. You don't see the damage in lower doses of amphetami

Comment · Mon, November 27, 2017 · 2 pts

Yes, but they are low on the list.

Comment · Mon, November 27, 2017 · 2 pts

40mg Vyvanse once a week shouldn't be an issue. It's higher dosages, or much longer regular use, that seems to be an issue. I can't say for sure on the Semax front, but I doubt it.

Comment · Tue, November 28, 2017 · 4 pts

Magnesium (glycinate or L-threonate), taurine, CoQ10, PQQ, L-theanine, vitamin E, vitamin C, L-carnosine, and ALCAR.

Comment · Thu, November 30, 2017 · 3 pts

Are you comparing it to racemic amphetamine, a mixture like Adderall, or just D-amphetamine? Because that's a big difference. The L-amphetamine is what gives it a lot of its "pushiness," so to speak.

Comment · Mon, December 4, 2017 · 3 pts

Ohh, ephedrine is very different than amphetamine. That's more of a peripheral stimulant, rather than a CNS dopaminergic one. So you will certainly get more euphoria from something that increases dopamine in the CNS.