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Comment · Fri, November 24, 2017 · Ceretropic & Nootropics Depot

The neurotoxic mechanisms of amphetamine: Step by step for striatal dopamine depletion -

What they were answering

gangsterio · -6 points

Amphetamine is......neurotoxic? What the fuck

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

Absolutely. Amphetamine can be neurotoxic in certain instances. That's usually dosage-dependent, but even long-term use of lower doses can lead to neurodegeneration. This seems to be especially true in younger people.

Amphetamine Treatment Similar to That Used in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder Damages Dopaminergic Nerve Endings in the Striatum of Adult Nonhuman Primates

Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brain

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

Generally, methylphenidate is safer than amphetamine. However, even that might lead to neurodegenration after time.

Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice

As a general rule, it seems that compounds that significantly increase levels of extracellular dopamine can damage the brain in certain instances.

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