Comment · Sat, September 30, 2017 · Ceretropic & Nootropics Depot

What does amidation do to epitalon?

Original post in this thread

phaganax · 2 points

I read that amidating the C-terminus of a peptide may increase its bioavailability and stability. Let's say I still have about 80mg of reconstituted N-acetyl epitalon amidate (Ceretropic) under cold storage conditions (fridge), and I haven't touched it since 7 weeks for a reason. Can it still be used?

I tag /u/MisterYouAreSoDumb . Maybe you can answer this question. Any input would be appreciated.

What they were answering

phaganax · 1 points

Thanks! The amidate form is very hard to dilute. Even with 10ml the 100mg didn't want to dilute. I gently rotated the vial yesterday to dissolve the tiny layer of peptide at the bottom, but now my solution got cloudy.

u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot

Yeah, it's very non-polar. It takes time to fully solvate. Cloudy is fine, though. You just don't want large particulates.

Going forward, we are going to start selling the 100mg in tow separate 10ml vials of 50mg, to allow easier dissolving.

Other MYASD lines in this thread

Comment · Thu, September 28, 2017 · 5 pts
Amidating a peptide protects the C-terminus from enzymatic degradation, and it also lowers the polarity of the Epitalon sequence. That makes it more lipid soluble, and able to pass the blood brain barrier better. Gener

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