Comment · Mon, September 19, 2016 · Ceretropic & Nootropics Depot
Cordyceps Cs-4 vs Cordyceps militaris, which is better?
Original post in this thread
tronatula · 11 points
Hi, I would like to try Cordyceps, but the price makes me have to think carefully.
/u/realmushrooms, Cordyceps Cs-4 has more research on it and is way cheaper, so what are the reasons to buy Cordyceps militaris, which is better for motivation? Does Cordyceps have cholinergic properties (aCHe inhibitor,....)? Cause I react badly to cholinergic stuff.
/u/MisterYouAreSoDumb, your CORDYCEPS 10:1 is more expensive yet why it has lower Beta-Glucan (β-Glucan) content (20% vs 30%)? Also, same question as above, does Cordyceps have cholinergic properties (aCHe inhibitor,....)?
What they were answering
tronatula · 2 points
Really? I've spent 1 hour to research about Cordyceps yet have not found any studies state Cordyceps inhibit AChe. In fact, this study tells the opposite:
Compared with the OP rats, the levels of amino acids (leucine, isoleucine, valine, lysine and tyrosine), sarcosine, O-phosphocholine and choline in the CS group declined, and these changes were accompanied by increases in the levels of N-acetylglutamine, glutathione, carnitine, taurine, glycine and NAD
Could you link me your studies please?
P/S: I've found this study states "we have recently identified that extracts from Cordyceps sinensis (CS) promote M1 mAChR function". But why Planetary Herbals Cordyceps Power CS-4 increased my digit span score? It contains:
Cordyceps sinensis Mycelia CS-4 (0.1% adenosine), Astragalus Root, Codonopsis Root, Adenophora Root, Eucommia Bark, Eleuthero Root, Bai-Zhu Atractylodes Rhizome and Ginger Root.
Which ingredient do you think made me better if I react poorly to cholinergics?
u/MisterYouAreSoDumb · Ceretropic & Nootropics Depot
Separation of CPSP can increase AChE inhibitory activity from the crude polysaccharide of C. militaris. CPSP-F1 and CPSP-F2 exhibited half maximal inhibitory concentrations of 32.2 ± 0.2 mg/mL and 5.3 ± 0.0 mg/mL. Thus, we identified polysaccharide–peptide complexes from C. militaris and suggest CPSP has great potential in AChE inhibition bioassay.
The pH 6.6-induced increase in acetylcholinesterase activity was inhibited by both actD and cordycepin in a concentration- and time-dependent manner.
INCREASED RATE OF ACETYLCHOLINESTERASE SYNTHESIS IN DIFFERENTIATING NEUROBLASTOMA CELLS
In contrast, cordycepin effectively blocked the increase in the rate of AChE synthesis that occurs as a result of serum deprivation
How do you know you react poorly to all cholinergics?