Comment · Sat, August 6, 2016
How does Tianeptine effect neurotransmitters other than serotonin
Original post in this thread
Sheepsaysmoo · 3 points
I have been taking Tianeptine (sulfate) and it has helped lift my mood and lower my chronic pain. However, this past week I have noticed more anxiety and less enjoyment out of things I'm doing.
Taking phenibut once a week is usually really enjoyable, however since starting tianeptine it has become almost pointless as I get nothing out of it. Music and things I'm interested in feel lifeless and boring. My goal was to find something that increases creativity not inhibits it. Kinda sucks because it was really helping.
I know it can enhance the release of dopamine. Might I be experiencing dopamine receptor down regulation? Also I've heard it can lower the amount of serotonin in the synapse, which would definitly explain some of my issues. What might I do to counteract these effects?
I'm going to start tapering down. Hopefully a lower dose still benefits me without some of the side effects. Does anyone have any insight into what might be causing these side effects?
What they were answering
jimmythegreek1 · 1 points
if I recall correctly, tianeptine doesn't have much of an effect on serotonin... at least, that is what I gathered by posts from /u/MisterYouAreSoDumb
u/MisterYouAreSoDumb
Tianeptine does lower synaptic serotonin levels, by enhancing its re-uptake. However, what the newer data showed was that was probably not the main mechanism of action for its antidepressant effects.