MK-677 availability??

Comment · Thu, June 30, 2016 · 8 pts

The second we get pure MK-677, we will have a batch made, and it will be up on the site. If you told me 6 months ago that we'd still be here right now screwing with impure batches, I would call you crazy. Yet here we are

Comment · Thu, June 30, 2016 · 5 pts

Thanks! I used to always trust 3rd party labs, because I did not know any better. Now that we have an in-house lab, and I am having to work directly with my analytical chemist on methods, I can see how methods can be man

Comment · Thu, June 30, 2016 · 3 pts

Yes we have. It's definitely an option. We'd need to create valid testing methods for that one too, though.

Comment · Fri, July 1, 2016 · 3 pts

I did with IRC.bio, to help them figure out their MK-677 issue. I don't with 3rd party labs, because if they kludged together misleading methods before, I don't trust them. Also, these 3rd party labs will not share their

Comment · Fri, July 1, 2016 · 2 pts

We still have not paid for the 7,8-DHF methods yet. All we are going off of is an FTIR comparison to Sigma Aldrich's reference standard, which all supply so far has not matched; including the what is currently being sold

Comment · Sat, July 2, 2016 · 2 pts

Yes, I have considered that. The issue is properly purifying it. If it is just ethyl acetate, then it is not a big deal to fix. However, there is another impurity we have yet to figure out.

Comment · Tue, July 5, 2016 · 2 pts

The IRC stuff we tested was 3% ethyl acetate and 3% something else. I do not know the second impurity yet. Our other batches were some solvent with a carboxyl group. Based on the synthesis, I thought it was benzyl chloro

Comment · Tue, July 5, 2016 · 2 pts

We do not have an NMR, unfortunately. We have an HPLC and FTIR. Dimethylformamide could be it as well. That is used in one of the synthesis methods I am seeing. Here is the paper where I am seeing the synthesis method

Comment · Tue, July 5, 2016 · 2 pts

We get it as the mesylate salt. Isobutyric acid could be it as well. I'd need some different equipment to really say for sure.

Comment · Tue, July 5, 2016 · 3 pts

What would be the steps to remove that?

Comment · Wed, July 6, 2016 · 3 pts

Yeah, that's what I thought. Seems like they rushed part of the synth, and it would take some doing to fix after the fact.

Comment · Thu, July 7, 2016 · 3 pts

No, she is more the analytical side (analytical forensics degree). I'll eventually bring some people on board with more organic/synthetic chemistry experience. Right now we are mostly doing analysis and QA/QC work. As we