Comment · Sun, July 12, 2015 · Ceretropic
DMSO-Dihexa ocular/eyeball delivery
Original post in this thread
dihexa · 5 points
After using Dihexa through different ROIs (IM, oral, transdermal DMSO, through the nose) and at different doses, I am a little frustrated that I haven't had any real 'success'/'breakthroughs' with it (beside a few vivid dreams), unlike others, who have posted their positive results across several forums.
I'm interested in using DMSO (75%) to dissolve what I have left of this hydrophobic peptide and then deliver it ocullarly to achieve maximum bioavailability. Besides IV (which isn't an option for me), there doesn't appear to be any decent ROIs with high enough bioavailability. I can't find much (officially) about the safety of applying DMSO to the eyeballs, which is my major concern... beside this paper excerpt from 1968:
if any single fact has emerged from animal and human studies with DMSO to date, it is that the lens toxicity findings originally reported in dogs and later confirmed in certain other species have no equivalent or counterpart in human therapy utilizing DMSO in generally accepted regimens.
My solution of DMSO-Dihexa would be about 30 drops in total. That's 50mg of Dihexa diluted in ~30 drops of 75% DMSO-saline to then be dropped into my eye/s.
What do you…
What they were answering
Debonaire_Death · 1 points
Could you weigh in on the 12 day half-life I've heard purported? It's difficult to believe but not out of the question.
u/MisterYouAreSoDumb · Ceretropic
It does have a long half life. It was 12 days in rats, when injected IV. The modifications to the peptide protect it from degradation much better than just N and C-terminal modifications.