Comment · Sun, July 12, 2015 · Ceretropic
DMSO-Dihexa ocular/eyeball delivery
Original post in this thread
dihexa · 5 points
After using Dihexa through different ROIs (IM, oral, transdermal DMSO, through the nose) and at different doses, I am a little frustrated that I haven't had any real 'success'/'breakthroughs' with it (beside a few vivid dreams), unlike others, who have posted their positive results across several forums.
I'm interested in using DMSO (75%) to dissolve what I have left of this hydrophobic peptide and then deliver it ocullarly to achieve maximum bioavailability. Besides IV (which isn't an option for me), there doesn't appear to be any decent ROIs with high enough bioavailability. I can't find much (officially) about the safety of applying DMSO to the eyeballs, which is my major concern... beside this paper excerpt from 1968:
if any single fact has emerged from animal and human studies with DMSO to date, it is that the lens toxicity findings originally reported in dogs and later confirmed in certain other species have no equivalent or counterpart in human therapy utilizing DMSO in generally accepted regimens.
My solution of DMSO-Dihexa would be about 30 drops in total. That's 50mg of Dihexa diluted in ~30 drops of 75% DMSO-saline to then be dropped into my eye/s.
What do you…
What they were answering
Debonaire_Death · 1 points
The two instances of neurotoxicity in humans cited in the article were large-scale IV infusions where DMSO was used as a preservative. In one instance, the subject was exposed to a combined total of approximately 18 grams of the stuff(!). The article itself is subjecting astrocytes in vitro to 10000ppm and 50000ppm DMSO solution for a 24 hour period, which seems dubious for comparison to the conditions of DMSO use as a delivery platform for a pharmaceutical.
I've decided to purchase this product for experimenting with a bi-weekly regimen of dihexa, since I already have a sample of the stuff.
Have you tried dihexa at all, yet? It seems to be everything from overwhelming, to satisfying, to underwhelming for people. I'm a bit worried about how much mine might have degraded in the mail, with the hot weather we've been having. I think I'm about done with peptides for this season--although I might give your temp-controlled service a try if there are any new SEMAX analogues.
u/MisterYouAreSoDumb · Ceretropic
Yes, the concentrations the neurotoxicity were seen at were very high. Low dose use for short periods probably won't be damaging. It's mostly the smell issues that made me drop its use.
I have not tried Dihexa yet. I've been speaking to a few people that have been trialling it for the past 6 months or so. So far I have not heard of anyone getting very good effects. I have heard a few reports of side effects, though.