Comment · Fri, April 17, 2015 · Ceretropic
Pulmonary delivery of peptides. Using e-cigarettes.
Original post in this thread
112358134 · 6 points
Is it possible to use e-cigarette to vaporize different peptides?
I am talking about Semax, Selank, P21 and Oxytocin.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871608/
This article is about pulmonary delivery of Oxytocin but it also mentions this:
"The pharmacodynamic activity in response to the nominally higher inhaled dose reflected the lower bioavailability via the pulmonary route, estimated to be 10-20% for peptide drugs."
Will peptides be stable if we heat them up to 200-300 degrees? And how do you increase bioavailability? Is it viable at all?
I am very curious and would appreciate any information on it.
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
Vaporizing peptides is a very difficult process. You are not going to be able to do it with consumer devices. Also, the amino acids present, and their sequences, are going to determine how heat-stable they are. Some peptides can handle heat more than others.
Peptides with Asparigine in the sequence are more prone to hydrolysis. Then if you have Glycine-Glycine bonds, or Asparigine-Glycine bonds, that peptide is more susceptible to deamidation. Then the free Asparigine can be hydrolyzed. Then you have oxidation, which is higher in peptides that contain Methionine and Cysteine. Heat speeds up all those processes, further adding to the complication.