Comment · Mon, January 12, 2015 · Ceretropic
Very confused about NAC.. Is it pro-glutamanergic or anti-glutamanergic? Pro-dopaminergic or anti-dopaminergic? All I see is 'modulates glutamate and dopamine' which isn't much help
Original post in this thread
Mushubeans · 24 points
Either way, too high a dose makes me feel depressed but I want to know what exactly it's doing.
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
It's a modulator of glutamate.
http://archpsyc.jamanetwork.com/article.aspx?articleid=483113
N-acetylcysteine is a hepatoprotective antioxidant that is converted to cystine, a substrate for the glutamate-cystine antiporter. This antiporter allows for the uptake of cystine, which causes the reverse transport of glutamate into the extracellular space, which stimulates inhibitory metabotropic glutamate receptors and, thereby, reduces synaptic release of glutamate.