Comment · Wed, January 7, 2015 · Ceretropic
Vitamin B12 supplementation has noticeable effect on me, yet it shouldn't. What gives?
Original post in this thread
ThirdHuman · 6 points
I took a sub-lingual Jarrow 5000 Methyl B-12 supplement, and felt more energetic and felt a dull sensation on my forhead.
The problem is that I researched B-12 defficiency on the internet and there is no way I have one given my diet.
What is going on? I have taken many noots before, and this doesn't feel like placebo. I feel like I am going insane because I can't convince myself that I the affect it had on me was illusory when it was more far noticeable than most other Nootropics. Is there any way B-12 could actually have an affect on me even if I am not deficient (or at least shouldn't be deficient)?
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u/MisterYouAreSoDumb · Ceretropic
Your VDR Taq mutation means that you will have a harder time creating vitamin D from sunlight, leading to slightly lower dopamine levels, and the requirement for more methyl groups. However, your COMT is only heterozygous. So you are not that low. That means methyl groups will be needed at some times, and not at others. If you had homozygous mutations on both VDR Taq and COMT, then you would need them all the time.
Your homozygous mutation on MTHFR C677T is what controls folate metabolism. So you should avoid things with a lot of folic acid in them, as you cannot metabolize them as quickly as you should. You may also want to take some methylfolate supplements, to help equalize things.
Your BHMT-08 mutation controls the short cut for converting homocysteine to methionine. That can affect your norepinephrine levels. Trimethylglycine is good for that, as it bypasses the normal methyl donation cycle with SAMe, and lowers your homocysteine levels.
So it's not simply about taking more methyl donors. The cycle is very complex, and each mutation alters things a bit. You might benefit from adding in some 5-MTHF, TMG, and possibly some Vitamin D in the AM.
My pleasure! Glad I can help!