Vitamin B12 supplementation has noticeable effect on me, yet it shouldn't. What gives?

Comment · Mon, January 5, 2015 · 11 pts

You are probably a poor methylator, like I am. It's not the B12 your a missing, it's the methyl groups. I bet if you took SAMe and TMG, you would feel it as well. Here are a few good threads about it: http://www.reddit

Comment · Tue, January 6, 2015 · 1 pts

Yeah, it is pretty pricey.

Comment · Tue, January 6, 2015 · 3 pts

Is that the only mutation you have?

Comment · Wed, January 7, 2015 · 5 pts

Your VDR Taq mutation means that you will have a harder time creating vitamin D from sunlight, leading to slightly lower dopamine levels, and the requirement for more methyl groups. However, your COMT is only heterozygou

Comment · Wed, January 7, 2015 · 2 pts

It's not as simple as that. The methylation cycle is very complex. Some people benefit from certain methyl donors, but not others. It all depends on your individual mutations.

Comment · Wed, January 7, 2015 · 2 pts

No problem! Let me know if/how those things workout for you, and certainly shoot me over his mutations when you get them. It would be interesting to compare them to yours. I need to try and get my parents to do the testi

Comment · Wed, January 7, 2015 · 3 pts

I might just go buy some kits for my parents now too! My mom was adopted, so the genetic data on her side is invaluable to me.

Comment · Wed, January 7, 2015 · 1 pts

Yeah, 20% off. However, I can only ship to one address. So I will have to have them come to me, then send them off to my parents (they are divorced in different states).

Comment · Wed, January 7, 2015 · 1 pts

Yes it will. You can also get a good idea with the current 23andMe testing.

Comment · Wed, January 7, 2015 · 1 pts

23andMe testing will tel you everything.

Comment · Wed, January 7, 2015 · 2 pts

Nobody uses the 23andMe site itself anymore. You get the results, and export the raw genetic data from 23andMe. Then you import that into Genetic Genie or Promethase. That is where you get the real good info. Just use 23

Comment · Wed, January 7, 2015 · 1 pts

Daily, if you are someone that is a poor methylator. The only issue is that it is expensive. Also, it can interact with serotonin releasers/re-uptake inhibitors, so be careful if you are on them.

Comment · Wed, January 7, 2015 · 1 pts

My pleasure!

Comment · Thu, January 8, 2015 · 1 pts

You can buy their SAMe, and return it if it doesn't work?

Comment · Thu, January 8, 2015 · 1 pts

Not a bad deal.

Comment · Thu, January 8, 2015 · 2 pts

You've got similar mutations to the guy above, with a few differences. Lower ability to make D from sunlight, and slow at converting homocysteine to methionine. However, you do not have the 677T or MAO-A mutations, so yo

Comment · Fri, January 9, 2015 · 1 pts

My pleasure!

Comment · Fri, January 9, 2015 · 1 pts

Generally, undermethylators need supplements that will donate methyl groups. That would be methylfolate, methyl B12, SAMe, TMG, etc. Overmethylators would need things that absorb methyl groups. That would be hydroxocobal