Comment · Sat, December 27, 2014 · Ceretropic
A potentially simple way to make tianeptine more stable and less hygroscopic.
Original post in this thread
Bukujutsu · 11 points
Came across this a few days ago while doing some googling for something. It's been discussed before that tianeptine may not just clump/gel with moisture, but degrade: www.reddit.com/r/Nootropics/comments/2kqt6d/psa_seems_tianeptine_doesnt_just_clump_with/
>MisterYouAreSoDumb Ceretropic 1 month ago Tianeptine degrades, so that stuck powder might not actually be as effective. There is a long carbon sidechain on tianeptine, that is very susceptible to oxidation and UV light. There are at least 3 known products that it degrades into. I am working on a way to make the powder more stable, though. http://www.ncbi.nlm.nih.gov/pubmed/17626716
I found a patent for an improved version which also lists some sustained release mechanisms: http://www.google.es/patents/US8198268
The present invention relates to a novel sulfate salt of tianeptine, particularly tianeptine hemisulfate monohydrate, with improved properties. Such improved properties can include, but are not limited to, hygroscopicity, physical stability, and solubility. The invention also provides novel pharmaceutical compositions comprising tianeptine sulfate salt, methods of making tianeptine sulfate salt, and related methods of…
What they were answering
hugon2 · 1 points
IIRC freebase form is less active/inactive so there's no point in selling that. But if there's a simple way to make it into the sulfate, maybe it's worth to try. What do you think?
u/MisterYouAreSoDumb · Ceretropic
It looks promising. I was reading about it, and some other methods, when trying to decide on what to go with for an extended release version. I have my supplier looking into it now.
I actually did not read the patent fully, so I missed the section detailing how you can use the sodium salt to make the sulphate salt. So this might actually be doable at home!