Comment · Sat, December 27, 2014 · Ceretropic
A potentially simple way to make tianeptine more stable and less hygroscopic.
Original post in this thread
Bukujutsu · 11 points
Came across this a few days ago while doing some googling for something. It's been discussed before that tianeptine may not just clump/gel with moisture, but degrade: www.reddit.com/r/Nootropics/comments/2kqt6d/psa_seems_tianeptine_doesnt_just_clump_with/
>MisterYouAreSoDumb Ceretropic 1 month ago Tianeptine degrades, so that stuck powder might not actually be as effective. There is a long carbon sidechain on tianeptine, that is very susceptible to oxidation and UV light. There are at least 3 known products that it degrades into. I am working on a way to make the powder more stable, though. http://www.ncbi.nlm.nih.gov/pubmed/17626716
I found a patent for an improved version which also lists some sustained release mechanisms: http://www.google.es/patents/US8198268
The present invention relates to a novel sulfate salt of tianeptine, particularly tianeptine hemisulfate monohydrate, with improved properties. Such improved properties can include, but are not limited to, hygroscopicity, physical stability, and solubility. The invention also provides novel pharmaceutical compositions comprising tianeptine sulfate salt, methods of making tianeptine sulfate salt, and related methods of…
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Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
That's a patent on how to make the sulfate salt. Most tianeptine you see for sale is already the sodium salt. ~~For this to work, you would need freebase tianeptine. Nobody sells that.~~
Edit: Nevermind. It seems you can use the sodium salt to make it. Hmmm