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Comment · Wed, November 19, 2014 · Ceretropic

Can someone help me make sense of a study I found?

Original post in this thread

redan-yadayada · 9 points

I'm talking about this study here:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088617

In the study the most effective dose used for mice was 0.1 mg/kg, which using the HED come out to be 0.008 mg/kg in humans, which then come out to be around 0.5 mg for an average human of weight, 70kg. This doesn't seem right, unless the extract specified in the study is something like 100x. And ideas?

What they were answering

NootUser · 1 points

The paper is from 2004 and outlines the metabolism of MDMA resulting in 5-HT neurotoxicity, and predates your post on the metabolites. In the metabolites thread, you wrote "my theory" 13 times, which is misleading.

u/MisterYouAreSoDumb · Ceretropic

It was my theory. I used many different sources to form that theory. I did not get that paper till after I made that post. I did not have full access to papers back then, so I had to use abstracts. Once I made the post, a guy messaged me asking if I needed him to get the full studies for me. Then he used his university access to download the ones I asked for, and gave them to me in a zip file. There might even be a comment of mine on that thread stating that a guy just got me the full studies, and I was reading through them. Obviously the full studies he got allowed me to get a lot more in depth, and confirmed a lot of my theory. Using what I found in those studies, I edited a lot of the specific compounds in the thread. I did not have the full story till that guy got me the studies. I thought it was a metabolite of MDA leading to the primary damage. I just did not know the exact compound.

So I am not sure what you are trying to get at. I am not the one doing the rat and primate studies, so I have to get that information from published research that is. There were multiple studies alluding to the metabolites being the cause, which is what set me off on the path I went on to form my theory. Then I was able to confirm a lot of it, using the full studies I was given after I made the post. I now have my own access to published research, so I can go straight there. But a couple years ago, when I was forming my theory, I did not. You can even read through a lot of the comments on that thread, and see me forming the connections as I found new information.

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