Comment · Wed, November 19, 2014 · Ceretropic
Can someone help me make sense of a study I found?
Original post in this thread
redan-yadayada · 9 points
I'm talking about this study here:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088617
In the study the most effective dose used for mice was 0.1 mg/kg, which using the HED come out to be 0.008 mg/kg in humans, which then come out to be around 0.5 mg for an average human of weight, 70kg. This doesn't seem right, unless the extract specified in the study is something like 100x. And ideas?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Ceretropic
Well the multiplier for mice is 5 instead of 6 for rats, so the HED would be .0135mg/kg. Still does not answer your question, though. I cannot make sense of why that low of a dosage had the best effect. That would be like me taking 1mg orally.
They even reference a study that used 140mg/kg and 280mg/kg: http://informahealthcare.com/doi/abs/10.3109/13880200903280034
It's either a mistake, or we are missing something fundamental.