Comment · Mon, September 29, 2014 · Ceretropic
Noopept self-experiment: no effects
What they were answering
gwern · 2 points
There are no studies investigating sublingual administration of noopept, and the relative bioavailabilities compared to oral/injection.
Alright fine, so when you wrote "At 9.8% oral bioavailability, Gwern's highest dose is only roughly 5mg. That's half the dosage I use sublingually. His 12mg oral dose is almost nothing.", you were speculating out your ass about what my highest dose translated to and how it's 'almost nothing'. Please mention that in the future when you are exasperatedly telling people how you've written up a billion times how sublingual is infinitely superior.
However, it would have been easy for you to include that in your study...For you to include a sublingual aspect to your personal study would not be difficult, and could give us more relevant data. Saying that you do not think it should be done, because nobody else has done a sublingual study, seems silly to me.
No, it would not have. Sublingual breaks blinding because I have no idea where to find a placebo which tastes exactly like Noopept's particular foulness. And without blinding, all it would have shown (besides, of course, being unpleasant to consume and a huge amount of work to double the already-huge-sample-size to allow any remotely accurate comparison of the effect sizes from oral and sublingual) is 'placebo effects are big'. This is why I was hoping your confident pronouncements were base…
u/MisterYouAreSoDumb · Ceretropic
We can certainly make you a solution that masks the taste. That is not hard at all. And I was not speculating out my ass. Your lowest dose of 12mg is almost nothing, when you take into account the oral bioavailability. You have the studies, and conceded that it is around 10%. I was merely mentioning that your highest oral dose, when taking bioavailability into account, was half the sublingual dose I take. There was no mention of anything being superior. I even mentioned many times that your results might not differ at all with sublingual. You are the one putting words in my mouth now. I brought up an extremely valid variable, that we can even help you control for with blinding, and you are getting upset at me for mentioning it.
You know what, don't worry about it. I'll figure out a way to run a trial for it.