Comment · Fri, August 29, 2014 · Ceretropic
Hydrafinil Report
Original post in this thread
[deleted] · 22 points
I received my shipment of Hydrafinil a few days ago and have dosed it 4 times at this point and feel as if I can give some good feedback as to it's effectiveness (on my own chemistry at least). Currently I am not stacking any other substances except for Magnesium Citrate and a Multivitamin and Nicotine Vaporized.
Day 1 - 53mg Hydrafinil (2x)
----------------------------------
>T:0 - Ingested the powder (odd consistency reminds me of Alpha-GPC, not sure if it's hydrophilic or something along those lines?)
>T:+30m - Started to feel the effects of the initial dose beyond what I imagine to be placebo. I'm generally slightly fatigued due to sleep deprivation for my working schedule this fatigue was removed almost completely.
>T:+1h - Effects are in full swing. This dosage is reminiscent of the higher doses of Adrafinil that I have tried however it feels cleaner subjectively. The wakefulness promotion given by Hydrafinil can only be described as clean stimulation (not in the same vein as standard stimulants).
>T+1.2h - Slight euphoria has been noted at this point. Not anything to write home about but I was getting a little bit more pleasure out of day to day activities.…
What they were answering
[deleted] · 3 points
/u/MisterYouAreSoDumb,
Just to better help both my and this subreddits understanding of Hydrafinil I was wondering how this really differs from more standard Methylphenidate style stimulants. You note that hydrafinil blocks the 5-HT6 receptor which causes an increases dopamine and norepinephrine. So this chemical is just functioning as an antagonist of the receptor? This causes higher concentrations of dopamine and norepinephrine in the frontal cortex. Whereas Ritalin is a norepinephrine and dopamine reuptake inhibitor which increase the amount of those transmitters in a different manner (by binding to the site in question and being effacious)?
That behavior in question still seems stimulant-like by increasing levels of these neurotransmitters. Any insight into the MOA of this chemical would be much appreciated :).
u/MisterYouAreSoDumb · Ceretropic
Yeah, it is all about the amount of increases, and what part of the brain they happen in. An increase in dopamine in the hippocampus is going to be very different than one in the frontal cortex. Similarly, an increase in dopamine due to blockage of the 5-HT6 receptor, is going to be very different than blocking the re-uptake of dopamine out of the synapse by blocking the DAT. DRIs are going to be more sensitizing, since the extracellular dopamine levels will be higher longer. This may lead to more DA receptor down-regulation than a sudden release of dopamine, but the DAT staying in play.