Comment · Thu, July 3, 2014 · Ceretropic
A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides
What they were answering
FrigoCoder · 3 points
I wonder if you could synthesize something selective for the neurologic effects, but not the hormonal regulatory effects.
Yeah that is my line of thinking as well.
Based on what I could piece together after a day of ~~research~~ browsing the net, I suspect Desmopressin and Vasopressin exert their effects on memory via an ACTH-dependent pathway. Semax is based on ACTH as well. Would worth to take a look into related peptide fragments.
Too bad I have zero knowledge in this topic :(
u/MisterYouAreSoDumb · Ceretropic
Our new P21 acts on the ACTH pathway too. It is was designed to be the most potent ACTH peptide, by reverse engineering endogenous ACTH peptides with the structure of a peptide sequence from cerebrolysin. They used epitope mapping of the known neutralizing antibodies to human CNTF to develop it. I am VERY excited to bring it out!