Comment · Thu, September 19, 2013 · Ceretropic
Simple supplements changing my life, how to start with the basics (Nootropics).
Original post in this thread
370921A · 118 points
Hello all!
This post is about my research and personal journey into Nootropics. The first section is mostly about my take aways after doing a lot of reading/research, and the second section is about my personal usage and effects.
To give some background... I became highly interested in Nootropics about 3 weeks ago, I'm getting ready to start an extremely challenging school and wanted to see what I could do externally to enhance my academic performance. After discovering the world of Nootropics, I immediately started absorbing everything I could get my hands on about the topic: Wikipedia articles, scientific studies, reddit posts, IRC chats, Erowid, online forums, Gwern's website (gwern.net), youtube videos, online market places (amazon comments), etc,. All of that research culminated into very few certainties about the sometimes muddled world of nootropics.
+ 1. Everyone's different; what works for one person may not work for you. Experience stories vary widely, drug sensitivity (dosage) can differ greatly for desired effects, etc,. Although there is some agreement on what effects certain Nootropics will cause, effects can be godsend perfect for some and terrible for others…
What they were answering
casconed · 9 points
Can you back this up with any studies? Examine cites controlled studies showing no tolerance with dosages as high as 2mg.
http://www.ncbi.nlm.nih.gov/pubmed/21091391
http://www.ncbi.nlm.nih.gov/pubmed/15532202
edit: links to studies
u/MisterYouAreSoDumb · Ceretropic
Melatonin treatment desensitizes MT1 receptors
Melatonin significantly decreased MT1 receptor cell surface expression only in MT1high cells after a 1-hr treatment. These results indicate that melatonin treatment desensitizes MT1 receptors
http://www.ncbi.nlm.nih.gov/pubmed/23432361
although a previous study reported beneficial short-term effects of melatonin on sleep in hemodialysis patients, in this long-term study the positive effects disappeared during follow up (6-12 months). Also the quality of life parameter vitality did not improve. Efforts should be made to elucidate the mechanism responsible for the loss of effect with chronic use.