Simple supplements changing my life, how to start with the basics (Nootropics).

Comment · Thu, September 19, 2013 · 14 pts

[Melatonin treatment desensitizes MT1 receptors](http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2007.00470.x/abstract;jsessionid=D2E9B432F7D0BA961A31D8B5ABE00041.d02t04?systemMessage=Wiley+Online+Library+will+be+

Comment · Thu, September 19, 2013 · 1 pts

Yes, that will work short-term. However, those benefits will diminish after long-term use.

Comment · Thu, September 19, 2013 · 1 pts

"More taste in every bite!"

Comment · Thu, September 19, 2013 · 1 pts

The study I linked below used 3mg per day. After 6-12 months of use, the gains seen in short-term use were lost. So yes, I would definitely take a tolerance break. Also, you might just try lowering to sub-miligram doses

Comment · Thu, September 19, 2013 · 3 pts

It is a great antioxidant. Not a lot of people know that. Can you still sleep without taking it?

Comment · Thu, September 19, 2013 · 1 pts

I agree. I actually suggest a high dose of it after MDMA, to scavenge free radicals. Not only does it not cause redox cycling, but it can continue scavenging even after it has already bound to an oxidative substance. How

Comment · Thu, September 19, 2013 · 3 pts

I know all about MDMA supplementation. It is what got me into neurochemistry. I've spent years researching it. Have a read through a couple of my posts on it. http://www.reddit.com/r/DrugNerds/comments/13lp0b/mdma_neuro

Comment · Thu, September 19, 2013 · 1 pts

I see them range from .5mg to 5mg. 5mg is the highest I have seen in a pill/capsule. Usually I just have 1mg tablets, then cut them in half.

Comment · Fri, September 20, 2013 · 14 pts

I was not conflating anything. I was giving you some studies that were interesting. http://wurtmanlab.mit.edu/static/pdf/1049.pdf > for the most part patients have not been able to use the lowest fully effective doses

Comment · Fri, September 20, 2013 · 5 pts

I use the Natrol brand, 1mg tablets. There is a paper from researchers at MIT that goes into why vendors sell such high doses. It's a good read. http://wurtmanlab.mit.edu/static/pdf/1049.pdf >Why are physiologic doses

Comment · Fri, September 20, 2013 · 8 pts

No worries. Sometimes it's hard to determine tone over the internet. I don't want to make it sound like I am an expert on melatonin. If there is evidence to contradict my stance, I am more than willing to consider it. H

Comment · Fri, September 20, 2013 · 1 pts

Do you have a scale? You can pour the caps out and weight out smaller amounts.

Comment · Fri, September 20, 2013 · 1 pts

That would be what I would do. If your scale is not accurate enough, you could try splitting the powder up by eyeballing it. Obviously won't be as accurate, but would be better than taking 10mg every night.

Comment · Fri, September 20, 2013 · 1 pts

Did you see my post on why that is? http://www.reddit.com/r/Nootropics/comments/1mpujk/simple_supplements_changing_my_life_how_to_start/ccbrfgo

Comment · Wed, January 29, 2014 · 1 pts

Because there was a patent on 1mg and lower melatonin for use in sleep disorders. So they got around the patent by increasing the dosage.