Comment · Wed, August 14, 2013
Mdma and pooping
Original post in this thread
[deleted] · 19 points
DAE poop more than usual the next few days? Why is that?
What they were answering
reductase · 3 points
You're right in that aspect, and I think you can find your citation in one of the articles I referenced in my reply. Still, you can't (correctly) say that MDMA is a serotonin agonist because it releases serotonin, which then agonizes 5-HT receptors.
u/MisterYouAreSoDumb
http://www.jneurosci.org/content/28/11/2933.short
http://molpharm.aspetjournals.org/content/63/6/1223.short
In contrast, the effects of direct activation of presynaptic and/or postsynaptic receptors by MDMA have received far less attention, despite the agonist actions of the drug itself at 5-HT2 receptors, in particular the 5-HT2B receptor.
It is an agonist at the 5-HT2B receptors.
Here we show that acute pharmacological inhibition or genetic ablation of the 5-HT2B receptor in mice completely abolishes MDMA-induced hyperlocomotion and 5-HT release in nucleus accumbens and ventral tegmental area. Furthermore, the 5-HT2B receptor dependence of MDMA-stimulated release of endogenous 5-HT from superfused midbrain synaptosomes suggests that 5-HT2B receptors act, unlike any other 5-HT receptor, presynaptically to affect MDMA-stimulated 5-HT release.
And here they are saying that the 5-HT2B agonism is key to the presynaptic 5-HT release. So it most definitely is an agonist, and that agonism is crucial to the effects. The SERT reversal may be directly controlled by the presynaptic 5-HT2B agonism, or allosterically mediated by it. But in any event, MDMA is a 5-HT agonist. It's just not a postsynaptic 5-HT1A agonist.