Comment · Tue, August 13, 2013
Original post in this thread
[deleted] · 19 points
DAE poop more than usual the next few days? Why is that?
What they were answering
[deleted] · 3 points
Piggybacking off of your response, it's a serotonergic reaction to MDMA, which is a serotonin antagonist.
u/MisterYouAreSoDumb
What?!? MDMA is a 5-HT agonist, NOT an antagonist.
Comment · Tue, August 13, 2013 · 3 pts
MDMA induces a release of vasopressin, which signals the body to retain water. Take some EGCG, and it will help.
Comment · Tue, August 13, 2013 · 1 pts
Correct. But it's not an antagonist. We were talking about it's effects on the gastrointestinal tract, which would be related to it's agonism of certain 5-HT sub-receptors. The release of 5-HT due to reversal of the SERT
Comment · Tue, August 13, 2013 · 3 pts
Central 5-HT cannot pass the blood brain barrier, so any increase in serotonin in the brain will not lead to an increase in the stomach. Since the SERT is not expressed in the periphery, and increases in peripheral serot
Comment · Wed, August 14, 2013 · 2 pts
http://www.jneurosci.org/content/28/11/2933.short http://molpharm.aspetjournals.org/content/63/6/1223.short >In contrast, the effects of direct activation of presynaptic and/or postsynaptic receptors by MDMA have recei
Comment · Wed, August 14, 2013 · 2 pts
Until this topic came up, I was not 100% clear on the mechanism either. I had assumed that it's actions were similar to amphetamine and the DAT, due their similar structure. However, it seems their mechanisms are actuall
Comment · Wed, August 14, 2013 · 1 pts
Exactly! I knew of the 5-HT2B agonism, and the risks it posed for cardiac tissue. It's the same risk 6-APB has, albeit much lower. However, I did not make the connection to the 5-HT2B agonism being essential for the 5-HT
Comment · Wed, August 14, 2013 · 1 pts
Hmmm, that would be an interesting way to attack it. Inhibit 5-HT2B in the periphery, but not centrally. [Antinociception in rat by sarpogrelate, a selective 5-HT receptor 2A antagonist, is peripheral](https://hotfile.c
**I'm going to copy what I wrote on another thread:** _____________________________________________________ YES! Keep your damn body temperatures down people! http://www.maps.org/publications/1998_malberg_1.pdf http:
Ativan (lorazepam) I was going to the Markus Schulz concert one night, here in Phoenix. At dinner, one of my friends rolls a pill across the table to me. He said it was an Ativan. I was like, ohh ok, thanks. I did not i
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabol
>Molly is like the 70s version of crack Wait, what? I think they got their equivocation backwards, and their demographics mixed up. >but because the drug is so highly addicting, he said, "They're buying a lot of it."
Don't ever admit anything to a police officer. EVER! The burden of proof is on them.
Replying to Mentran · Why no redosing?
The metabolism characteristics of the drug mean that the first dose inhibits the main metabolic pathway, CYP2D6. This means that any subsequent doses are more likely to use the secondary metabolic pathway, CYP3A4. The CY