Comment · Thu, May 16, 2013 · Ceretropic
GEBR-7B, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses.
Original post in this thread
MisterYouAreSoDumb · 32 points
It looks very interesting. It seems to selectively inhibit PDE4D in the brain, causing hippocampal cAMP (cyclic adenosine monophosphate) levels to rise. This enhances cascading signals via the adenylate cyclase pathway. The AC pathways are linked to various types of spatial and procedural learning.
Here is an article about type 3 AC receptors being involved in novel object recognition in mice.
Here is a full paper about AC type 5 being involved in plasticity and learning.
Here is an article about cAMP and Mg2+ involvement in long-term potentiation.
What they were answering
sgijoe · 2 points
sooo ~20 doses at $5 per dose?... I wonder what the half life is.
u/MisterYouAreSoDumb · Ceretropic
Do you have a scale that accurate? It would take some pretty accurate equipment and some calculations to get a human dose. Plus, those were intraperitoneal. I'm not sure how the oral bioavailability would differ.