Skip to content

Comment · Tue, April 30, 2013 · Ceretropic

"I continue to discourage personal use until the drug is proved to be safe." - Fulvio Gualtieri, former researcher on sunifiram.

Original post in this thread

shrillthrill · 62 points

via here

Just a reminder that not everything labelled nootropic has been demonstrated safe in humans, despite it being available to buy from NSN.

What they were answering

must_warn_others · 2 points

What makes you think its mechanism is analogous to Piracetam?

The glycine-binding site activity and action via CaM kinase II and PKC sounds more like Nefiracetam to me.

u/MisterYouAreSoDumb · Ceretropic

Sorry, not the mechanism, the effects. The mechanism does sound most like nefiracetam. However, the effects it produces seem to mirror the effects of high dose piracetam. They seem to be going about modulating the NMDA receptor in different ways, but with similar results.

Other MYASD lines in this thread

Related in the archive

Postr/NootropicsJan 24, 2013

LiftMode Phenylpiracetam

My free shipment of phenylpiracetam arrived from LiftMode this morning. The packaging is very nice, and it included a detailed COA. It seems to be an in-house test, but it includes the actual data output and graphs from

2856PiracetamPhenylpiracetamNefiracetamCOA
Commentr/NootropicsMar 13, 2016

How is the nootropic laws in the US going to change?

Replying to norepinephrinex · You know, I'm not sure if I buy this argument. If you look on Usenet archives going back to the early 90's, people were making the exact same arguments , and that era was near the

The more untested and research-oriented compounds are such a minuscule part of the industry as a whole. It's not a risk comparatively. Just look at the same search trend graphs with Piracetam and Modafinil added to it:

6PiracetamNefiracetamNSI-189Modafinil
Commentr/NootropicsMay 4, 2020

Agmatine 2.0

Replying to vertigho · Got it, this makes sense. Thank you for the thoughtful response. I'll explore racetams as a potential option to speed up the process. Given that you noted kratom also has NMDA anta

1) It's hard to say. Nefiracetam might be good, as that binds to the glycine site of the NMDAR. However, I am not convinced of its safety. You can be safe and start with the tried and true piracetam, and go from there.

4PiracetamNefiracetamAgmatineDosing
Commentr/NootropicsAug 15, 2013

Can you build tolerance on racetams? (+ Noopept)

Replying to [deleted] · [deleted]

Racetams are not pointless without choline. There are a lot of other actions they have apart from facilitating ACh transmission. You also cannot bundle all the racetams together like that. Many of them have very differe

3NoopeptPiracetamAniracetamPhenylpiracetam
Commentr/NootropicsDec 1, 2012

A Worthy Nootropics Vendor. Great deals up to Nov. 30th and great customer service.

Replying to vxc · Interesting that this more potent analog has a toxicity profile, while piracetam and aniracetam were shown to be unable to produce any toxic effects (iirc, an LD1 couldn't even be

Well the molecule is significantly different. The toxicity arises from one of it's metabolites. [See this figure.](http://toxsci.oxfordjournals.org/content/72/1/164/F1.large.jpg) M-10 is the one they believe is the cause

3PiracetamAniracetamNefiracetamRacetams
Commentr/NootropicsMar 19, 2013

Acetylcholinesterase Inhibitors and Bedtime

Replying to multiple_sclerotia · On this sub I read multiple times that one should also refrain from racetams before bedtime. Do you think this is an accurate advice? I have never seen any evidence that racetams (

http://www.ncbi.nlm.nih.gov/pubmed/210850 >Both Vincamine and Piracetam in doses of 1 and 300 mg/kg p.o., respectively, enhance absolute and relative amounts of paradoxical sleep (PS). Smaller doses have a lesser or no

2NoopeptPiracetamNefiracetamDosing