Comment · Sat, December 1, 2012 · Ceretropic

A Worthy Nootropics Vendor. Great deals up to Nov. 30th and great customer service.

What they were answering

vxc · 3 points

Interesting that this more potent analog has a toxicity profile, while piracetam and aniracetam were shown to be unable to produce any toxic effects (iirc, an LD1 couldn't even be found in rodents, and they gave up trying. the lack of any toxic effects was the [hilarious] reasoning behind the FDA ruling against classifying piracetam as a drug).

u/MisterYouAreSoDumb · Ceretropic

Well the molecule is significantly different. The toxicity arises from one of it's metabolites. See this figure. M-10 is the one they believe is the cause of the toxicity. Animals metabolize nefiracetam differently than we do, so humans may not have the same issue.

http://toxsci.oxfordjournals.org/content/72/1/164.full

http://144.206.159.178/ft/1043/92678/1612206.pdf

Other MYASD lines in this thread

Comment · Fri, November 30, 2012 · 4 pts
http://www.ncbi.nlm.nih.gov/pubmed/15082078?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/12849691 http://www.ncbi.nlm.nih.gov/pubmed/8667455 Does that toxicity manifest in humans? There is not conclusive evidence

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