Comment · Mon, April 29, 2013 · Ceretropic
"I continue to discourage personal use until the drug is proved to be safe." - Fulvio Gualtieri, former researcher on sunifiram.
Original post in this thread
shrillthrill · 62 points
Just a reminder that not everything labelled nootropic has been demonstrated safe in humans, despite it being available to buy from NSN.
What they were answering
gwern · 8 points
Statistically, you are correct.
The best kind of correct.
However, given what we know about the receptor affinities, it's very unlikely that the human pharmacodynamics of unifiram and sunifiram will differ from the animal models.
You don't think that isn't what every other researcher giving the go-ahead for human trials based on sterling animal model results could say?
With the known possible issues with other compounds people are trying to source, I would say sunifiram is the least of our worries. Just take a look at IDRA-21. That has known issues with exacerbating glutamate toxicity, yet people are trying to source it to try. ...However, I also know that many people are going to chance taking those substances anyway.
:(
u/MisterYouAreSoDumb · Ceretropic
I'm not disagreeing with you. I am just a realist and know people. Given the knowledge we have, I am not super worried about sunifiram. Would I suggest for someone to start taking it? No, I wouldn't. However, I am interested in the results people are getting.
Also, being exposed to the people in /r/Drugs taking unknown RC chems all the time has made me used to the fact that people are going to ingest untested chemicals no matter what evidence we have. If we can steer them away from the most dangerous ones, then at least it helps.