Comment · Thu, November 22, 2012
MDMA Neurotoxicity Part 1 (Metabolites)
Original post in this thread
MisterYouAreSoDumb · 77 points
This is probably going to be the first in a series of discussions I start about MDMA. There's just too much information for one post. Therefore, I am going to start with one that is very interesting to me: MDMA's metabolites and their role in neurotoxicity. I pre-appologise for the length and terminology used.
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First off, let's discuss how MDMA is metabolized. The human cytochrome CYP450 is responsible for the metabolism of MDMA. The primary enzyme responsible is CYP2D6, using O-demethylation. This process adds two hydrogen atoms to the two open oxygen atoms in MDMA to create HHMA. Let's look at the structure for a minute.
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MDMA is 3,4-methylenedioxy-N-methylamphetamine
HHMA is 3,4-dihydroxy-N-methylamphetamine
So your CYP2D6 enzyme added two hydrogen atoms to the methylenedioxy structure to create a dihydroxy structure. Once it's been o-demethylated to HHMA, it is no longer active like MDMA is. HHMA can then be 0-methylated further to HMMA, or 4-hydroxy-3-methoxy-N-methylamphetamine. Here is an image to help you visualize this process.
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Tenvelden · 1 points
Very interesting post even though I'm not a very scientific person. I can appreciate the immense amount of research you must have done but I want to ask: At the end of the day is this mental degradation preventable and how?
u/MisterYouAreSoDumb
Yes, it's fully preventable. I'll copy what I wrote to another person below.
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I will do a big supplementation post soon. Here is a general idea.
Take fully chelated magnesium glycinate before and during. Doctor's Best brand is a good one.
Take a good alpha lipoic acid supplement before, and one each hour of your roll.
Take an EGCG (green tea extract), along with grape seed extract before and during.
Drink some grapefruit juice before your drop, then halfway through the night. I also take a quercetin supplement before drop as well.
I drink an Emergen-C packet in water a couple hours before drop, then usually halfway through the night. At the club, I just order ice water, then mix in the Emergen-C that I keep in my back pocket.
I also take a couple Tums 30min before my drop, because all the Emergen-C and grapefruit juice will make your stomach acidic. You want to lower that so that your MDMA absorbs faster. Then throughout the night you are taking Emergen-C and grapefruit juice, which raises the acidity again. This helps you pee out much of the MDMA before it can metabolize.
5-6 hours after drop, if you have an SSRI like Prozac, take it. I also take 5mg of melatonin before bed.
Then the next few days I take EGCG with 5-HTP, as well as piracetam and various antioxidants.
I have all my supplements organized ahead of time in a labeled pill container. It makes it easy. A little prep work makes a world of difference!