Archive

How much did they put in this?!

Replying to Ashamed-Status-9668 · It has a pretty hefty dose Vitamin B2 which is what makes your pee so yellow.

Temporarily. With daily use it goes clear again. Riboflavin is absorbed via saturable carrier-mediated transport (RFVT1/2/3 transporters) in the small intestine, then converted in the intestinal mucosa, liver, heart, and kidneys into its active coenzyme forms: flavin mononucleoti…

🚨 By Popular Demand: InfiniFiber & InfiniGreens Are Now 3 Per Order 🚨

Replying to CrimsonMax · Hi MYASD, unrelated but can we get higher count bottles of PanaMAX since schisandra capsules and powders are getting discontinued? Maybe a 180, 240 or even a 360 count bottles. I r…

I'd have to do some analysis to see. If we did, we would likely replace the 120ct, not add a 3rd SKU. We need to consolidate units, if anything.

Concerns about Cistanche Supercritical Extract & Steroidogenesis: Does Acteoside/Verbascoside actually drop Testosterone? (Looking at this 2015 study)

No, and most people are missing a massive fundamental point in the bioactives. Acteoside and echinacoside are both large, polar, heavily glycosylated molecules (~624 Da and ~786 Da respectively) with multiple sugar units. They are glycosides that are too large to absorb into the…

UK supplement manufacturer actually runs his capsule and tablet machines with and without fillers and added ingredients, thought this is cool and informative

Replying to UniqueBasil1937 · Government also puts chlorine and fluoride in water so you don't get sick but it doesn't mean is good for you. They add anti-caking agents in table salts (calcium silicates and sil…

First off, MCC is the ideal filler for a bunch of reasons: * **Compressibility and flow:** MCC exhibits excellent powder flow properties. We us multiple grades (PH 101, PH 102, PH 200) for different formulation requirements. This enables consistent capsule fill weights and dosing…

⚠️ InfiniFiber is Now Live! Our Advanced Synbiotic Fiber⚠️

Replying to bottleofink · Any chance you'll release the PHGG on its own? I'm a little nervous about this full stack because I deal with SIBO on and off.

We probably won't release PHGG on its own. That being said, InfiniFiber should be compatible with people that have SIBO. The fiber sources that are an issue for that scenario are ones with fructans (no inulin, no chicory, no wheat) and no fructooligosaccharides. You want to have…

Infinigreens vs Green Vibrance

Replying to Extra-Art8589 · Yea, I was drawn to their formulas and zero fillers...maybe it was too good to be true. https://thesynergycompany.com/blogs/news/organic-vitamins-your-body-will-feel-the-differenc…

There's literally no evidence of even scientific explanation from them for those claims. They just say it without evidence. That's a marketing trick. To even know the quality of your ingredients, you need to at least test for them and standardize to bioactives. Even so, let's pre…

Amazon bought Ashwagandha

Replying to Warren_sl · Thank god Maitake is coming back. How much ergothioneine per serving for each product and around what time frame?! Secondly approximately when is the new myostatin mushroom coming?

We are having a vitamin D stack that will contain 5mg ergothioneine in it. Then we are having a standalone ergothioneine stack with 25mg in it. That way you can combine them both for 30mg/day. Myostatin stack will be out soon, in the next month or two. We are just waiting on the…

ALCAR not recommended anymore!

Alright, I've read through this study, and there are some important things we need to discuss before everyone panics about TMAO and throws their ALCAR in the trash. The first is the TMAO causation problem. Let's be very clear about something, there are zero human interventional t…

Alcohol Question - Supplements to Prevent the Damage?

Replying to mbvlover25 · NAC, Milk Thistle & Tudca

You have to be really careful with TUDCA and alcohol. Let me break this down, as there's a lot of confusion around TUDCA and alcohol timing. Many companies say that you should avoid TUDCA within 24 hours of consuming alcohol. However, the whole "24-hour rule" thing isn't as black…

Our Black Friday Sale 2025 is officially live!

Replying to Visual-Reply-5401 · >the earlier study on hearing loss in the elderly Hi, /u/MisterYouAreSoDumb. Would you be able to answer a question I have about this? I’m actually in the process of advocating fo…

I was wrong in those old comments. We worked with the authors of those papers to solve the issue. Erinacine A was being destroyed in the sample prep process, so we thought there was no erinacine A in there, when it was just being destroyed in the lab process. My former lab direct…

Any good site or app that shows which supplements are actually backed by science?

Replying to voyager256 · Yeah Examine is great, but I skimmed through the ND links you provided , but everything seems vague and I’d say even sketchy. E.g. It doesn’t seem like any of the scientific board …

You're saying doctor Lindsay Faucette, who is double board certified in family medicine and integrative medicine, didn't "study and graduate medical studies?" Is that what you are saying? Are you also saying that someone with a PhD in nutrition, and who helps patients fix their d…

⚠️ NEW PRODUCTS ALERT | Cyatherm Capsules, Lucidimax Capsules, Peruvian Black Maca Powder, Mushroom Magic Powder, Mushroom Magic Advanced Powder, & TUDCA Capsules⚠️

Replying to ArcticPlatypus · Oh that is amazing to hear that it is the highest macamide contained in the extract! The paper didn’t seem to clarify if it was a trace macamide or one of the dominant macamides in…

> Does your team use any calculations to estimate serum concentrations of molecules in the extracts? We do use ADME to estimate pharmacokinetics and inform our formulations. It can help get a picture of things, but it is only an estimate based on the available data. >I know all m…

⚠️ NEW PRODUCTS ALERT | Cyatherm Capsules, Lucidimax Capsules, Peruvian Black Maca Powder, Mushroom Magic Powder, Mushroom Magic Advanced Powder, & TUDCA Capsules⚠️

Replying to Auslander-Buchsbaum · Finasteride at the standard 1mg dose/day increases testosterone levels (this effects peaks at around 15% after 6 weeks of treatment, then diminishes, 10% increase from baseline aft…

Thanks for the study reference! It looks like the reduction of testosterone is when people with BPH taking higher doses of finasteride. [Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperpla…

⚠️ NEW PRODUCTS ALERT | Cyatherm Capsules, Lucidimax Capsules, Peruvian Black Maca Powder, Mushroom Magic Powder, Mushroom Magic Advanced Powder, & TUDCA Capsules⚠️

Replying to togden94 · Iv noticed these new products don't have stack recommendations, will they be added? Iv also noticed that some recommendations have been removed from other product pages, what is go…

Ohh, good catch! I hadn't noticed. I will get those added in. As for other removals, what do you mean specifically? Just stack suggestions? Our website is all controlled by our custom backend now, where all the data is stored on every product. That includes stack suggestions. Tha…

⚠️ NEW PRODUCT RELEASES ARE COMING 07/31/25 | Three Mystery Products, Mushroom Magic Magic Powder Blend, Mushroom Magic Advanced Powder Blend & TUDCA⚠️

Replying to Warm_Ad_6177 · There was an in vitro study with human liver cells that concluded that pre-treatment with TUDCA markedly increased cell damage by alcohol, though there were benefits through a diff…

I actually wrote a pretty good overview of the issue with TUDCA and alcohol. https://reddit.com/r/NootropicsDepot/comments/1ipimsj/milk_thistle_is_beneficial_to_the_liver_fact_or/mcyj7jp/

Ecklonia Cava Sun Protection Questions

The off switch for the sun for me was at higher doses. I am talking like 2g. That completely stopped me from even tanning, much less burning. As you go down in dosing, the effects do as well. Lower doses reduce the severity of burning, but doesn't completely stop it. 500mg per da…

Ecklonia Cava Sun Protection Questions

Replying to Hhabberrnnessikk · I've been taking 500mg a day for a little over a week. I am extremely white, and usually get a bad burn in the beginning of summer then wont burn again. I went swimming for 4 hours…

My testing with completely eliminating sunburns was after 4 weeks of daily dosing. It needs time to build up. Also, it is dose-dependent. The more you take, the less likely you will burn at all. Lower amounts reduce, but don't eliminate it. In fact, I went up as well. Higher dose…

Infinigreens is amazing

Replying to CrimsonMax · I quickly realized almost all the other greens on the market are trash. Plus you don't even know what the actual ingredients are and the toxicity levels as most of these greens are…

I know people think I am just saying shit to sell more product, but everyone else's products are just total trash. There is no scientific thought behind their formulas. The ingredients don't make any sense. The dosing doesn't make any sense. They charge lower total prices, but th…

⚠️ NEW PRODUCT ALERT | Eurycomax Capsules, InfiniGreens Powder, & Ecklonia cava Powder⚠️

Replying to pancakestacker641 · new tongkat looks promising! few questions: 1) AM or PM dosing schedule? essentially, does it impact sleep? 2) TK10% always gives me horrible brain fog -- not sure why. does t…

1) AM dosing is best 2) Not knowing your personal brain chemistry, it is hard to say. However, it should be less likely to do it. 3) No issues there. I actually like the combo with kanna. 4) No, you should be fine.

⚠️ NEW PRODUCT ALERT | Eurycomax Capsules, InfiniGreens Powder, & Ecklonia cava Powder⚠️

Replying to legosandplants · The greens looks good, but that’s almost 50% more in cost than most greens on the market.

Most greens on the market suck dick, and are dosed much lower than ours. This is 15.5 grams per dose. Go look at the shitty greens out there and see what they are dosing at. Moreover, most brands are just buying premade greens mixes from their contract manufacturer, with no real…

Sleep Support combined with Tauromag and Magnesium Glycinate

Replying to [deleted] · [deleted]

You do realize that the current AI tools are large LANGUAGE models, right? They have no way of knowing what is actual fact. They are responding to the language you use in your prompt. By these responses, I can assume your prompt was formed in such a way that was asking to disprov…

⚠️ NEW PRODUCT ALERT | Ecklonia cava Capsules⚠️

Replying to ManufacturerThat3715 · With all due respect I’m not sure this is correct. The product is “seapolynol” aka SEANOL-P, referring to the alcohol extract of ecklonia cava containing 90%+ phlorotannins. So…

They are referring to seapolynol, which we got a sample of and tested in our lab. They don't sell it outside Korea anymore, but we set up a facility in Korea to do all this stuff. It had around 4% dieckol, where ours is hovering just below 1%. It's nowhere near 90% phlorotannins…

⚠️ NEW PRODUCT ALERT | Ecklonia cava Capsules⚠️

Replying to ManufacturerThat3715 · I’m confused, the EFSA say phlorotannins can go up to 263mg // day. Yet we have 0.5% dieckol or 1.25mg. Can you clarify?

The name of the product submitted to the EFSA was "Ecklonia cava phlorotannins." So when they approved it, they specifically referenced the full name in the submission. They were not referencing the amount of actual phlorotannins in the product. >The Panel concludes that the nove…

⚠️ NEW PRODUCT ALERT | Ecklonia cava Capsules⚠️

Replying to IncreasinglyTrippy · I have questions: 1. Does it contain iodine? 2. It’s an AMPK activator and a sleep enhancer? Should it be taken in the morning or before bed then? 3. What exactly are its effects…

1) Yes, it should naturally contain some iodine. That will range by time of year and where it was harvested. The typical levels are 220-650 mg/kg. That would be between 55mcg and 162mcg per capsule of ours. I can talk to my lab and see if we can do an iodine assay to know the exa…

Is ND done launching new products?

Replying to redditintheAM · Have you tested BrocElite? Supposedly it’s the only other stabilized sulforaphane and has a few other related compounds added to it.

Yes, it has 2.87mg of sulforaphane per dose. However, after 2 hours in SGF and then 2 hours in SIF, only 0.87mg is left over; so I am not sure how much is getting into your system. Also, they claim 10mg, but there is only 2.87mg. This is probably because it is not really stable l…