Comment · Fri, April 4, 2025 · ND Owner
⚠️ NEW PRODUCT ALERT | Ecklonia cava Capsules⚠️
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NDSocialMedia · 60 points
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What they were answering
IncreasinglyTrippy · 25 points
I have questions:
1. Does it contain iodine?
2. It’s an AMPK activator and a sleep enhancer? Should it be taken in the morning or before bed then?
3. What exactly are its effects on gaba receptors, that’s a little unclear.
4. Please share staff experience
u/MisterYouAreSoDumb · ND Owner
1) Yes, it should naturally contain some iodine. That will range by time of year and where it was harvested. The typical levels are 220-650 mg/kg. That would be between 55mcg and 162mcg per capsule of ours. I can talk to my lab and see if we can do an iodine assay to know the exact amount in this batch. We also based our dosing off the EFSA novel food approval, which assessed iodine levels.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7010033/
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2) Yes, it activates AMPK through direct phosphorylation, but also reduces ROS in mitochondria, which lowers AMP/ATP ratios. This protects cells from the increase in AMPK. It then also increases adenosine, by inhibiting adenosine deaminase. That adenosine will bind to the A1 receptors, counteracting the AMPK effects on wakefulness.
Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways
Preventing Parkinson's disease may lie in seaweed antioxidants
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3) It is a positive allosteric modulator of GABA through the GABA-A receptor, at the benzodiazepine binding site.
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4) I notice better sleep and improved hair growth while on it. I also notice less systemic inflammation on days that I take it.
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5) Yes, it can lower DHT through 5-AR inhibition, albeit to a lower level than something like finasteride. The other phlorotannins have also been shown to offset androgen receptor down-regulation that you can get with things like finasteride. For people that don't want to lower DHT, but want the other benefits, I would suggest taking Tribugen with it. In fact, some researchers combined Ecklonia bicyclis (different species, but still contains dieckol) with Tribulus terrestris, and it improved sexual function.