Comment · Sat, October 4, 2025 · ND Owner
Longvida consistently potentiates cannabis???
Original post in this thread
ThisIsCreativeAF · 21 points
So I've been occasionally taking Longvida and every time I take it, it seems to potentiate smoked cannabis quite significantly (even 8+ hours after taking Longvida). I'm curious if anyone else has experienced this? I've heard of people using turmeric/curcumin to potentiate things before, but wasn't expecting it to work this well. I actually don't take it very much because it can potentiate it to an uncomfortable extent for me as I'm fairly prone to get some anxiety from THC.
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Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
Yes, by its MAOI activities. It can also help reduce the memory side effects of cannabis, by inhibiting COX-2.
Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling
Regulation of COX and LOX by curcumin
So it can increase the stimulating effects, while making you more lucid. This can be useful for some, but counterproductive for others.