Comment · Thu, March 13, 2025 · ND Owner
Is ND done launching new products?
Original post in this thread
Experienced8 · 31 points
Title is self explanatory. No new products in 2025 yet...
Feels like the energy of the this subreddit has absolutely cratered lately.
What they were answering
weltweite · 1 points
I remember DatBTrue (peptide guru) back in the day really liked Cell Logics EnduraCell broccoli sprout powder. I also remember emailing back and forth with their head biochemist (I was a biochemist in my previous career), and they impressed me with their process considering how many products on the market fail to produce sulforaphane. Definitely would be curious if you tested their product as well!
I remember asking about enteric coating as well and their response back then was:
"Enteric protection is used when bioactive compounds may be destroyed by the acid and enzyme secretions of the stomach; the process is useful for some compounds. However, sulforaphane begins to be produced as soon as the broccoli sprout powder (EnduraCell in this case) becomes moist. This means that sulforaphane starts being released in the mouth if the powder is ingested – and in the stomach if non-enteric capsules are ingested. There are benefits in having it present throughout the digestive tract. For example, there are 3 clinical trials to show that sulforaphane effectively controls the Helicobacter pylori bacterium that inhabits the stomach wall and can cause gastritis, reflux and ulceration. So why bypass the stomach with an enteric coating?
The competitor’s product doesn’t fully disclose how they have added the myrosinase activity to their glucoraphanin extract, although there is a…
u/MisterYouAreSoDumb · ND Owner
It's a lot more complex than that, and broccoli sprouts are not a good source for a reason that many people don't know about: epithiospecifier protein (ESP). Many brassica species have ESP in them. What is ESP? ESP functions as a non-catalytic cofactor of myrosinase, the enzyme responsible for hydrolyzing glucosinolates like glucoraphanin. When myrosinase converts glucoraphanin in isolation, you get sulforaphane. However, when ESP is present with the myrosinase, this catalyzes the conversion to sulforaphane nitrile. That is completely inactive in the body. Broccoli sprouts are high in ESP. This means that using broccoli sprouts as your glucoraphanin source is not ideal.
The other complexity that brands don't take into consideration is the fact that myrosinase is not a single static thing. It's a class of enzymes, and each source of myrosinase will have higher or lower affinities to certain reactions. This is why choosing which brassica you get your myrosinase from is crucial. Since glucoraphanin is not the only glucosinolate in there, the affinity of the specific myrosinase matters a lot to the amounts and types of isothiocyanates that ultimately get created. In fact, multiple distinct subfamilies of myrosinase have been identified: MYR I (including MA, MB, MC, AtTGG1-3) and MYR II (including AtTGG4 and 5). Add that to the fact that different cofactors present (like ESP) will affect the metabolism greatly, and you can see why it can get complex in these interactions. To further complicate it, myrosinase will completely deactivate in stomach acid in a matter of minutes. The EnduraCell people saying that you can just take their broccoli sprout powder and have it start converting in your mouth is just stupid. Very little, if any, will get created in the short time it is in your mouth, then the myrosinase will be deactivated right when it hits your stomach. By the time it reaches the more neutral conditions of the small intestine, there will be no myrosinase left to catalyze the conversion to sulforaphane. They are correct in saying that having sulforaphane present earlier has shown benefits. However, their product will not make any by that point, so it is moot. They would know that if they had done some pharmacokinetic testing.