Comment · Wed, March 12, 2025 · ND Owner
Is ND done launching new products?
Original post in this thread
Experienced8 · 31 points
Title is self explanatory. No new products in 2025 yet...
Feels like the energy of the this subreddit has absolutely cratered lately.
What they were answering
CurrentlyAltered · 2 points
Hey, just wondering, your write up about isoliquitoritigenin is all about GABA b effects etc but further research shows it binds to the bzd receptor 65 times more than diazepam. Of course that doesn’t mean its effects are as potent even if it has more affinity for the receptor, but I’d take this as a warning to people trying to control/balance their mood and whatnot when coming off of certain things thinking it’ll help. I bought it to help with a taper but looking into how it’s used in TCM and the research they’ve done shows me I may have made a mistake. It does seem like it’ll be super useful when I’m at the end of the taper, but I find it crazy because it read as the ideal compound to rid yourself of something with gaba b affinity and yet research shows way more than gaba b activity going on. You should update the write up 🤷♂️
(I am tapering a gaba a bzd agonist and gaba b agonist with sodium potassium and calcium gated channel effects if ya catch my drift. Just about done the gaba b one and though iso could have made the rest of this easier 😑)
u/MisterYouAreSoDumb · ND Owner
Google is weird with the word benzodiazepine. If it shows up anywhere on a page, everything gets disapproved. It's dumb, because that's the name of the binding site, not just the drugs that bind to it. However, good luck getting Google to understand that. Sometimes we have to avoid certain words because of stupid Google policies.