Comment · Sat, November 30, 2024 · ND Owner

Cognance Bacopa

Original post in this thread

Lazlo25 · 8 points

I'm finally buying Cognance Bacopa as part of my black friday shopping.

Since it is a PAM of 5HT2A, does that mean it should make Serotonergics like SSRIS and espeically psychadelics stronger?

Any insight or experiences would be greatly appreciated!
u/Misteryouaresodumb I'm lookin at you :0

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · ND Owner

It depends on the relative binding affinities of the 5-HT2A agonist you are combining it with, but yes. I have noticed that Cognance potentiates other seritonergics. What I have really found synergizes with it are dopaminergics, though.

Other MYASD lines in this thread

Comment · Sun, December 1, 2024 · 7 pts
[Serotonin 5-HT2 Receptor Interactions with Dopamine Function: Implications for Therapeutics in Cocaine Use Disorder](https://pmc.ncbi.nlm.nih.gov/articles/PMC4279075/) [Anatomical relationships between serotonin 5-HT2A

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