Comment · Mon, September 16, 2024 · Natrium Health & Nootropics Depot
A Potential New Nootropic (SYNTHESISED AND TRIED) results
Original post in this thread
cmnews08 · 339 points
If you didn't see the original, take a look here
Anyways, to start let me post the synthesis.
I chose to not include the dichloro aspect of the original post as I knew it would cause serotonin interactions and that's where the potential harm could be, I didn't want to create a serotonin reuptake inhibitor which is what I theorised the dichloro would cause.
Let me say, this synthesis took a lot of money, time and effort before I got a good yield. I am working on a more cost and time effective synthesis.
I synthesised this from a base chemical, Phenyl(piperidin-2-yl)methanol, which is pricey at about $200 (£152.38) a gram. Leaving little room for error.
Reacting this with thiourea and Chloroethane gave an intermediate with deaminated to a product that could be reacted carefully with Sulfuryl chloride, Ammonia and Hydrogen peroxide would give the chemical I wanted.
I failed 5 times before I got it right, costing me close to $700 (£530), however I finally…
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Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
This looks very similar to a modafinil derivative that I found in an old Cephalon patent years ago, and had synthesized for us. It had much higher dopamine affinities than modafinil. I beta tested it out on myself, and it was crazy effective! It was somewhat like halfway between modafinil and amphetamine in effects. That molecule only had one chlorine group, though. Yours has two. The position on the benzene ring that the phenyl group was attached to was also different. Yours is essentially modafinil with two chloro groups on one ring, and one of the phenyl groups turned into a piperidine group. The one we made kept the two phenyl groups from modafinil, but made one into a chlorophenyl group, and modified the position it attached to the other benzene ring. It's been years since I tried out the other analog, but I'd be curious to see how similar in effects yours is.