Comment · Mon, September 9, 2024 · ND Owner
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NDSocialMedia · 44 points
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What they were answering
TheGermanGuy21 · 4 points
Maybe you could use L-Selenomethionine, like in the NOW selenium product.
u/MisterYouAreSoDumb · ND Owner
The issue is that L-selenomethionine has shown to be inferior to selenium-enriched yeast.
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.850935/full
In conclusion, both SeY and Sel-Met promoted cell viability and attenuated cell apoptosis by regulating the selenoprotein expression and antioxidative capacity via p38/JNK signaling pathway in PMEC, but SeY has more efficient benefits than that of Sel-Met.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125492/
Overall, we showed for the first time, reductions in biomarkers of oxidative stress following supplementation with SY but not SeMet in healthy men. These findings suggest that selenium-containing compounds other than SeMet may account for the decrease in oxidative stress.
https://www.mdpi.com/2072-6643/6/10/4002
Tissues particularly sensitive to changes in selenium supply include red blood cells, kidney and muscle. The meta-analysis identified that for animal species selenium-enriched foods were more effective than selenomethionine at increasing GPx activity.
So selenium-enriched yeast is just superior to L-selenomethionine. The same goes for other selenium forms.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251790/
In conclusion, in this study selenium-enriched yeast was more effective in enhancing nutrient digestibility, and inhibiting inflammation and oxidative stress by inducing the activity of the lymphocytes, expression of antioxidant enzymes and so on.
The reason for that is because selenium-enriched yeast bioconverts it to protein-bound L-selenomethionine, but also creates L-selenocysteine and L-methylselenocysteine. It's the latter two that seem to be the most effective.
https://journals.co.za/doi/abs/10.10520/EJC-6775ff5a9
It has been confirmed that, compared with mineral selenium, its organic forms are better absorbed and therefore serve selenium needs more effectively. Research has revealed that selenium incorporated as selenocysteine (SeCys) is the key amino acid (AA) supporting the antioxidant properties of most of the 25 selenoproteins identified in animal species or humans, such as glutathione peroxidase, thioredoxin reductase and methionine sulfoxide reductase. However, this SeCys has to be synthetised de novo by the cells and cannot be supplied through feeds. Dietary SeCys undergoes complete transformation to selenide (H2Se) to synthesise de novo SeCys.
This is why it is a challenge for us to swap this one out. Selenium-enriched yeast is by far the superior form of selenium for most people.