Comment · Thu, August 17, 2023 · ND Owner
🎙️Lion's Mane Mushroom Q&A | Post Your Questions From Our Latest Podcast Episode!🎧
Original post in this thread
NootropicsDepotGuru · 18 points
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Our latest episode of the In Search of Insight podcast is a deep dive into our new Lion’s Mane Mycelium supplement. Emiel, James, and Erika discuss building out Omnient labs, developing our Erinacine A standardization process, and the mechanisms of action that make this Lion’s Mane Mycelium powerful for nerve health and cognition.
Have you watched the new episode yet? We want to hear your questions! Post your question in the thread below and tag Emiel u/Pretty-Chill or u/Omnient_Labs so you can learn more about Lion’s Mane Mushroom, its health benefits, and why this mycelium supplement stands out from the crowd.
Watch this month's podcast episode on YouTube and Spotify, and listen on Soundcloud, [Apple Podcasts](https://podcasts.apple.com/us/podcast/in-search-of-insight/id1…
What they were answering
lewanay · 3 points
Why did you guys decide to go with a 2.5 mg Erinacine A serving?
The only human double blind placebo trial using Erinacine A I could find is this study from Taiwan which used 15 mg.
Li, I-Chen, et al. "Prevention of early Alzheimer’s disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study." Frontiers in aging neuroscience 12 (2020): 155.
Even with such a high dose, the group receiving Erinacines had a 2 point improvement in MMSE on average, compared to placebo, which makes me wonder how people here are reporting perceptible changes within days. I have been taking 1-2 servings daily for prevention. Can't say I've noticed anything significant. I am wondering if I should increase the dose further.
u/MisterYouAreSoDumb · ND Owner
https://www.frontiersin.org/articles/10.3389/fnagi.2020.00155/full
That study didn't use 15mg erinacine-A per day. It used 350mg of an equivalent of what Erinamax is, 3X per day. So essentially they were taking 1 gram of Erinamax a day. We spoke to the authors of that study, and they confirmed the dosing with us.
This study comprised of a 3-week no-drug screening period, followed by a 49-week double-blind treatment period with 2-parallel groups in which eligible patients were randomized to either three 350 mg/capsules containing 5 mg/g erinacine A per day or identical appearing placebo capsules with meals. This dose was chosen according to a previous study design (Li et al., 2019) and converted to human dose as specified by FDA guidelines (FDA, 2005). Cognitive assessments, ophthalmic examinations, biomarker collection, and neuroimaging were followed throughout the study period. Written informed consent from all patients or their legal representatives was obtained before their enrollment.
That's 350mg doses of a 5mg/g erinacine-A mycelium, which is 0.5%. That's the same as Erinamax. That means they were getting 5mg of erinacine-A a day. That's why we did 500mg tablets, and a 60ct small size, so people could take two if they wanted and still have 30 days.