Comment · Sun, February 20, 2022 · ND Owner
Slc12a8 possibly not an NMN transporter?
Original post in this thread
__shamir__ · 3 points
I came across an article, ["Absence of evidence that Slc12a8 encodes
a nicotinamide mononucleotide transporter"](https://sci-hub.hkvisa.net/10.1038/s42255-019-0085-0#), which appears to debunk [at least some of] the evidence presented in Slc12a8 is a nicotinamide mononucleotide transporter for Slc12a8's action as an NMN transporter. The article is quite brief so I won't quote from it, but it basically disputes the validity of the techniques used (especially from a chemistry / biochemistry perspective from what I can gather)
OTOH, some of the findings in Slc12a8 is a nicotinamide mononucleotide transporter seem pretty definitive. But if the argument of the critique, namely that the analytical methods were invalid/flawed holds, then I suppose it can't necessarily be trusted. Here's some quotes from a relevant subsection, "Biochemical features of the Slc12a8 protein":
> Next, we overexpressed the full-length mouse Slc12a8 cDNA in mouse NIH3T3 cells. We chose this cell line because it does not have any detectable extracellular activities of CD73 (converting NM…
What they were answering
LungsOfSteel · 3 points
Dr. Alessia Grozio is Elevant’s Chief Scientist and Elevant sells their own product NMN-C.
u/MisterYouAreSoDumb · ND Owner
Holy shit! I did not know that! Well there's conflicts on both sides it seems... Still, the data that Grozio put out is solid, and the arguments from Schmidt and Brenner don't hold water IMO. I will have to research the relationship between Grozio and Elevant. It says she is a scientific advisor. I wonder if she has ownership in the company? It looks like they only registered the domain in 2020, and the original research came out in 2019.
https://whois.domaintools.com/elevant.co
So it looks like she got involved in Elevant after her research was published. That would explain why there was no competing interests section on the study.