Comment · Thu, November 19, 2020 · ND Owner
Questions about Quercetin bioavailability
Original post in this thread
BoozeAndHotpants · 10 points
I have read many conflicting studies on the relative bioavailability of Quercetin. I know there are manufacturers that use lecithin to create “phytosome” versions to increase absorption and utilization, but I also know that sometimes just taking a greater amount of a lesser bioavailable form is often the most economical option. Do you guys at ND (or anyone else) have any guidance or knowledge on this?
Here is an example for illustration purposes only; not speaking about the quality of the study at all, just to show the type of study that makes it confusing to pick a quality quercetin supplement:
https://www.nutraingredients-usa.com/Article/2018/10/30/Overcoming-the-low-bioavailability-hurdle-of-quercetin-Indena-study-supports-phytosome-use-to-boost-absorption
“Despite the potential benefits, bioavailability of quercetin is low with estimations that only 20% of the administered dose reaches the blood.
This is where Indena’s use of a delivery system based on food-grade lecithin offers a solution: According to data published in European Journal of Drug Metabolism and Pharmacokinetics the Quercetin Phytosome (Quercefit) proved to be up to 20-fold more bioavailable.”
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
I discussed it a few times.
Moral of the story is that normal quercetin raises plasma level in humans with regular dosing. That's why we decided to that one first. I am not opposed to a higher bioavailability version, but the cost/benefit is not going to be there for most people. I eve personally tried EMIQ, or ezymatically modified isoquercetin, and found that to just amplify the side effects while costing a lot more. I will get some of the phytosome in to personally try, though.