Comment · Fri, November 6, 2020 · ND Owner

Lion's Mane Mushroom (1:1 extract) or 7,8-Dihydroxyflavone

Original post in this thread

jarrellt67 · 9 points

I've picked up both supplements for the reported cognitive effects. However, before starting with one of them I'm curious as to which one everyone has better effects with for that, and for reducing anxious feelings and increasing mood (as that will be the one I'll likely try solo first...before later maybe trying the combination).

What they were answering

xrkq9s · 2 points

Any receptor regulation concerns?

u/MisterYouAreSoDumb · ND Owner

You mean from down-regulation? Not at reasonable doses. Also, polygala up-regulates TrkB receptors. So combos with polygala are a good way to regulate that. That being said, high levels of any ligand can lead to down-regulation of its receptor. So it is more about dose/concentration than anything. We are only releasing 4-DMA-7,8-DHF in reasonable dose capsules.

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