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Comment · Mon, October 5, 2020 · Natrium Health & Nootropics Depot

What dose (mg) of Lion’s Mane do you take?

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[deleted] · 84 points

I take 500mg daily. I’m wondering if there are people who take more, or tried more, and what difference it made for them.

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Stay_Calm_Recover_On · 1 points

u/MisterYouAreSoDumb what's the theoretical equivalent of Hot Water Extract to 8:1 in terms of Hericenones? Can I assume there are 8x the amount of cognition boosting compounds in the 8:1? Is taking 1g of the 8:1 like taking 3g of 1:1 when it comes to Hericenones? Assuming I only care about the cognition benefits.

u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot

Absolutely not. That's not how extraction ratios work. You don't just get 8X more of the main active you want. It's much more complicated than that. The only way to verify hericenones is via validated assay methods, which don't exist at the moment. Everyone claiming them is pushing a false and fake number. We have spoken to the lab that is doing it for them, and they have a history of bad science and fabricated results. They will not give ANY details on their assay method, and basically said that their owner has a PhD, so we should just trust her... So you absolutely cannot trust any hericenone number at the moment.

If you just want what is closest to the few human clinical studies on lion's mane, straight up 1:1 powder is it. ~~There are no human clinical studies on mycelium.~~ (Till recently there were none. The new studies are on an erinacine-A enriched extract, not normal mycelium). There are no human clinical studies on a dual water/ethanol extract from the fruiting bodies, either. Our 8:1 extract was a first attempt at making a more concentrated extract, and many people prefer the effects. However, that is anecdotal. There are only a few human studies on lion's mane, and they only used ground up fruiting body powder. Everything else is speculation at this point, or educated guesses based off animal studies. Anyone saying otherwise is being disingenuous.

So why would we use ethanol? Well most hericenones are not soluble in water. So it makes zero sense to do an 8:1 water extract. You might as well just take a higher dose of the 1:1 at that point. It makes ZERO sense to do a concentrated water extract of lion's mane, unless you are only wanting to concentrate things other than hericenones. That's fine to do. There are other water-soluble things you might want in there. However, most people are looking for the cognitive effects, which most of the evidence is on hericenones. So using ethanol helps to pull more of those over.

Now the only real way we are going to solve this issue is with validated assay methods for both hericenones and erinacines. We already have methods for a couple of the erinacines, which we have used to assay many extracts on the market. Spoiler alert: they do NOT contain detectable amounts. Yes, even the ones claiming to. They are all below detection limits of about 0.1%. We are working on hericenones, but we don't have validated methods for any of those yet. I am hoping to by the end of the year, though. Only then can we start really getting some data on the fruiting body products out there. Till our science end is finished, we are not adding new extracts or changing the existing ones. It's what we have sold for years, so we are keeping it consistent till we have all our science buttoned up. However, once that happens we will be developing and releasing new extracts. I've already personally taken a few, and they are insanely potent.

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