Comment · Fri, October 2, 2020 · ND Owner

Polygala and Mast Cell

Original post in this thread

Robbiemeanswell · 7 points

Hi friends,
I have mast cell activation syndrome which means I often react poorly to foods and supplements that antagonize the H1 and H2 receptors. Does anyone know if polygala works on these receptors at all? Polygala has changed my life but I need to make sure it isn’t reactivating my mast cell response. Really, I’m looking for nootropics that will work on my serotonin and dopamine without causing a mast cell response. Any input in greatly appreciated.

What they were answering

Direct reply to the original post — see the thread post above.

u/MisterYouAreSoDumb · ND Owner

I have a mast cell disorder, too. I have never had any issues with polygala affecting my histamine response. In fact, there is evidence that polygala might help with mast cell degranulation.

Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway

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Comment · Mon, October 5, 2020 · 4 pts
Cetirizine is the only reliable thing that works for me.

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