Comment · Fri, July 24, 2020 · ND Owner
Polygala Sublingual Tablets
Original post in this thread
varvela · 11 points
First of all, I LOVE your Polygala extract. It’s precisely the Nootropic I’ve been looking for to give me the mental energy and focus to do my work for long periods of time. So hats off to you guys for this one.
What I’m wondering is if I could expect sublingual tablets/solution for the foreseeable future? It’s only that route of administration that gives me the right effect and I can’t exactly be weighing powders on my desk at work.
Secondly, side question, what in theory would Polygala do to the brain with chronic use (what kinds of up/down-regulations would occur for example)?
What they were answering
varvela · 2 points
Great to hear! I have read the blog, it was a great read.
Not being very knowledgeable on the neuropharmacology though, I get a little uneasy when I see reuptake inhibition because it makes me think those neurotransmitters will be downregulated in the long term to bring the brain back to homeostasis. So I guess that’s an example of what I’m wondering about. Is that concern based on a faulty assumption?
u/MisterYouAreSoDumb · ND Owner
Not necessarily a faulty assumption, but a misinterpretation of scale. If you were taking pure Yuanzhi-1 then I might be more concerned. However, polygala as a whole is not a super strong reuptake inhibitor. So there is little risk there. Polygala actually gets more effective over time, as it builds up in your system. So I would not worry about down-regulation.