Comment · Mon, May 4, 2020 · Natrium Health & Nootropics Depot
Agmatine 2.0
Original post in this thread
vertigho · 11 points
Hi, I posted here about my experience with agmatine sulfate and kratom in late-October 2019. The story I described went as follows (please note I had been taking kratom for \~2 years prior to taking the agmatine):
1.) I took \~1.50g agmatine on two separate occasions over the course of 2-3 days, with the intent of simultaneously reducing my kratom dose ... I didn't reduce my kratom dose (which in hindsight may have been a mistake).
2.) following these agmatine doses, I ceased agmatine and continued taking kratom at my normal amount.
3.) since taking the agmatine, my emotional range, euphoria experienced via kratom (and euphoria experienced in general), and general sense of color in the world has been completely stunted. I was optimistic this would clear with time away from agmatine, but no-dice.
Fast forward 7 months to now, I am still feeling a different baseline mood and different reaction to kratom than I was pre-agmatine. Another thing I've noticed is that time seems to move faster in a very subtle but consistently noticeable way, and I often have a headband-like pressure headache, most noticeable on the sides of my head, and I often feel an emptiness in the front of my he…
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
Agmatine is an NMDA antagonist. Your brain is quite literally less malleable. That's what NMDA receptor antagonists do. Also, 1.5 grams is a massive dose for agmatine. It's not permanent, though. If you want to speed the process up, you can take a positive allosteric modulator of NMDA. Many of the racetams do that. Kratom also has NMDA antagonists in it. They seem to be more present in the stems than the leaves. Kratom also affects the kappa opioid receptors, which can cause dysphoria. Kratom also affects serotonin and dopamine re-uptake. So there are many mechanisms at play.