Comment · Fri, April 3, 2020
Which product might mimic Pseudoephedrine benefits on ND?
Original post in this thread
YoYoYL · 6 points
So, Pseudoephedrine is the strongest most beneficial supplement I took for concentration (actually took it as part of a cough medicine). It showed me that I'm able to have much better executive function and short term memory.
I've been looking for a nootropic or a supplement(s) that can affect the same receptors or act more on NE than dopamine. I'm more prone to having my CNS triggered by amphetamines, so I'm trying to find something else that can be used for a long period of time with less worries (Pseudoephedrine has many side effects).
Thank you!
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
Your best bet would be a combo of berberine, polygala, and caffeine.
Pharmacological effects of berberine on mood disorders
Either acute or chronic administration of berberine at low doses results in increased levels of NE, 5‐HT, and DA in whole‐brain samples. Kulkarni et al showed that acute administration of berberine (5 mg/kg, i.p.) in mice caused increased levels of norepinephrine (31%), serotonin (47%), and dopamine (31%). Chronic administration of berberine (5 mg/kg, ip) for 15 days significantly increased the levels of norepinephrine (29%), serotonin (19%) as well as dopamine (52%).
Norepinephrine Transporter Inhibitors from Polygala tenuifolia