Comment · Mon, March 2, 2020
Doubts about Gotu Kola's potential side effects
Original post in this thread
faxmulder · 4 points
Hi folks,
M34, normal-weight, bloodworks (overall parameters and hormones) fine, except low vit D and LH levels (the latter probably caused by low-grade varicocele).
I'd interested in trying Gotu Kola for my issues, i.e. focus, brain fog, mild anxiety and repetitive checking/OCD behaviours, dry skin, cold hands.
I've seen that GT is often advised for "being more in the present", thus I believe it could be useful in my situation.
My current daily stack is: multivitamin, resveratrol, curcumin, vit D, chlorella, N-Acetyl Glucosamine, polygala, agmatine, magnesium, grape seed extract and ornithine (for deeper sleep).
Pre-workout stack: PanaMax ginseng (cycled with rhodiola and cordyceps), alpha GPC, dynamine, citrulline, taurine and forskolin (I'm considering adding also carnosine/beta-alanine).
I have a few questions:
* Do you see any potential bad interaction or overlap by adding Gotu Kola to my daily stack?
* GT's effects on libido and testosterone production: I've seen a reference on Examine and some scary stories about testicle shrinkage :-/
* Is it okay to take agmatine daily, or would it be better to take only on workout days?
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Tha…
What they were answering
edefakiel · 0 points
We are seeing the damage done by endocrine disruptors already, it is not worth it to keep messing with our hormones and organs.
Serum testosterone level was reduced in all treatment groups. www.ncbi.nlm.nih.gov/pubmed/20589353
The number of apoptotic germ cells per seminiferous tubule cross-section was significantly increased in the experimental group (18.11 ± 3.5) compared with the control group (8.7 ± 0.81) (P < 0.05). Serum testosterone, follicle-stimulating hormone, and luteinizing hormone levels also showed significant decreases in the experimental groups (P < 0.05). There was also a significant decrease in testis weight in experimental groups compared with the control group (P < 0.05). It is concluded that Centella asiatica has toxicological effects on the reproductive system in male rats. www.ncbi.nlm.nih.gov/pubmed/21870191
u/MisterYouAreSoDumb
That study used 300mg/kg for 42 days! That would be like me using 3.6 GRAMS of an ethanol extract of gotu kola per day for 42 days... We cannot use that study as a basis for determining what normal doses do in humans. They even state that the other 100mg/kg and 200mg/kg did not show as potent effects, but they don't even release the data on it. Those doses could have shown zero adverse effects. Can't know without the data. However, I suspect they left that data out for a reason. It did not fit their narrative. The 100/200mg/kg doses are still insanely high. If they showed zero effects, then it would throw their conclusions off. I do not trust that study. Also, that study does NOT say it affected any hormones. It talks about it possibly limiting spermatogenesis by a reduction in sorbitol dehydrogenase. Again, it's entirely speculation at this point.