Comment · Mon, March 2, 2020
Doubts about Gotu Kola's potential side effects
Original post in this thread
faxmulder · 4 points
Hi folks,
M34, normal-weight, bloodworks (overall parameters and hormones) fine, except low vit D and LH levels (the latter probably caused by low-grade varicocele).
I'd interested in trying Gotu Kola for my issues, i.e. focus, brain fog, mild anxiety and repetitive checking/OCD behaviours, dry skin, cold hands.
I've seen that GT is often advised for "being more in the present", thus I believe it could be useful in my situation.
My current daily stack is: multivitamin, resveratrol, curcumin, vit D, chlorella, N-Acetyl Glucosamine, polygala, agmatine, magnesium, grape seed extract and ornithine (for deeper sleep).
Pre-workout stack: PanaMax ginseng (cycled with rhodiola and cordyceps), alpha GPC, dynamine, citrulline, taurine and forskolin (I'm considering adding also carnosine/beta-alanine).
I have a few questions:
* Do you see any potential bad interaction or overlap by adding Gotu Kola to my daily stack?
* GT's effects on libido and testosterone production: I've seen a reference on Examine and some scary stories about testicle shrinkage :-/
* Is it okay to take agmatine daily, or would it be better to take only on workout days?
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Tha…
What they were answering
edefakiel · 1 points
The dosing in the second study was way more reasonable:
"The experimental groups received orally 10, 50, 80 and 100 mg/kg aqueous leaf extract daily for 60 days and the control group received just water. "
And it does indeed say that it affected the hormones, as I copied.
"Serum testosterone, follicle-stimulating hormone, and luteinizing hormone levels also showed significant decreases in the experimental groups (P < 0.05). "
I tried to Sci-Hub it, but:
Sci-Hub
! Ошибка: не удалось открыть страницу
попробовать еще раз ➝
So I don't have more details.
I think that you maybe only read the first one, which was admittedly the least interesting, and maybe not entirely worth sharing it, for the reasons that you have pointed out.
u/MisterYouAreSoDumb
Yeah, I was talking about the first study.
Here is the second: https://sci-hub.tw/10.1007/s11418-011-0578-y
The oral LD50 of the extract of Centella asiatica was calculated with Pharm/Pcs probit scale versus log dose, valuer=0.96, standard deviation=0.5 and regression equation, and found to be 200 mg/kg with a confidence of1.9–2.2 in male rats. A dose of 100 mg/kg/day showed significant changes in the reproductive system.
So the 200mg/kg is the LD50 in rats! We are talking ridiculous doses here. Then the 100mg/kg dose did not show significant changes in the reproductive system. If you look at the table data, testosterone went UP at the 10mg/kg dose. LOL.
Isothankuniside and thankuniside are the two things most likely for this effect in gotu kola.
https://pdfs.semanticscholar.org/38ce/821a64e9e299bb3fd5d9c4e8ecf0c10be6a4.pdf