Comment · Thu, July 4, 2019 · Natrium Health & Nootropics Depot
I just discovered a NATURAL Dopamine (D2) Agonist + DRI
Original post in this thread
Lokzo55 · 44 points
LAURELIA NOVAE-ZELANDIE EXTRACT (-PUKATEA-).
Māori used the bark of the tall pukatea (Laurelia novae-zelandiae) tree as a painkiller, boiling the inner layer to make a decoction. Pulped inner bark was also held in the mouth to ease toothache. Pukatea bark contains pukateine, which has a chemical structure similar to morphine. It was first isolated in 1910 by Bernard Aston, the first chemist at the Department of Agriculture.
Pukatea is supposedly an analgesic similar to morphine (Similar chemical structure).
This herb contains a Pukateine which is a D1/2 receptor agonist (IC50: 0,4/0,6 muM) but also a dopamine reuptake inhibitor with an IC50 of 46muM.
The D2 receptor agonism (like LSD, Salvinorin A and anti-parkinson drugs) may explain the reported dissociative effects.
It also shows alpha1-adrenoceptor affinity and antioxidant activity.
I have personally not trialled this herb for any purposes, however, it has piqued my interest.
Let's get some discussion going!
What they were answering
darkpenguin22 · 1 points
I don't think I got quality sleep, though.
I'd recommend an Oura ring (https://ouraring.com/) for better quantitative assessments of sleep when trying out new stuff.
For example, I discovered taurine makes a large positive impact on my nighttime HRV. (on average adding 30ms+ over no taurine before bed)
u/MisterYouAreSoDumb · Natrium Health & Nootropics Depot
This thing is pretty sweet! Apparently my sleep sucks! I've always thought I was okay, since I fall asleep right away. Most nights the Oura ring shows 0 minute sleep latency. So I was under the incorrect assumption that I was sleeping well, when in fact my sleep quality was kinds shitty! I am not getting enough deep sleep. I am waking up multiple time, even though I don't remember it. This data is pretty cool! I am getting some good baseline data that I can compare to when I start taking our sleep stack daily.